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6. We avoid the following:
This sounds really good, but who/what is the CIR? Cosmeticsinfo.org is sponsored by "the trade association representing the cosmetic, toiletry and fragrance industry in the United States and globally. Founded in 1894, the Council has a membership of more than 600 companies including manufacturers, distributors, and suppliers of the vast majority of finished personal care products marketed in the United States." This would be like going to a site sponsored by the pharmaceutical industry to get information about your medication. Major conflict of interest going on here, which greatly enhances the potential for bias. It does not mean that their claims are bogus, but does mean you cannot just take them at face value.
Disclaimer: I'm not knocking the pharmaceutical industry, as I once worked at one of the largest pharmaceutical companies in the world and by and large had positive experiences there. Bottom line, however, you have to approach information critically and take into account any potential for bias or conflicts of interest.
So ideally, to really get an accurate picture, you would need some type of systematic review/meta-analysis from an impartial party that looks at the original research and synthesizes it. Barring that, you would need to evaluate the original research on your own. Dr. Pickart had recommended searching PubMed using the search terms "hyaluronan cancer". That will indeed give you oodles of citations (almost 2,500), but we are concerned with topical use of Hyaluronic acid. So add "topical" to the search, and you actually start getting studies looking at the topical uses of Hyaluronic acid. One study looked at a gel containing Hyaluronic acid vs. usual care to prevent contact radiation dermatitis in breast cancer patients. Interestingly, the study was stopped before completion because the women treated with the Hyaluronic acid gel developed contact dermatitis at a significantly higher rate than those who were not. To see this abstract, just type in the number 22172912 (the PMID, a unique identifier) into the PubMed search box.
If you take cancer out of the equation and do a search using these terms "hyaluronic acid topical skin", you find some interesting articles. I learned that for wound care, "Harnessing the therapeutic action of hyaluronan into a topical application of proven clinical benefit has proved challenging." (PMID 22068141) Another study did find that low molecular weight Hyaluronic acid resulted in significant wrinkle reduction in the eye area (PMID 22052267). This one even had some interesting before and after pictures. However, the concern that started this whole post isn't so much does Hyaluronic acid work (which is a whole 'nother topic), but is it safe?
|11 lbs of Hyaluronic Acid would cost you $3,672.90|